Amasawa Yoichiro was abandoned by his parents and has been wandering the world alone. Some trouble leads to his encounter with a shy university student Suzuki Nita who hopes to become an artist. A penniless and homeless Yoichiro makes Nita buy him curry on the grounds that he saved him, and mutters briefly about his family. Kiyokawa Kaoruko who runs Kiyokawa Realty has been keeping the ashes of Yoichiro’s late father because she used to be the caretaker of his apartment. There appears to be some significant reason why Yoichiro tries out curry every day.

When Shoutarou Tatewaki first meets Sakurako Kujou, he knows his life will never be the same. Initially believing her to be responsible for a disappearance in the neighborhood, he later learns of her true talent: analyzing bone specimens. Sakurako has quite the collection of reconstructed animal bones, but she wishes she had more of the human variety, much to the chagrin of those around her. Soon, Shoutarou begins accompanying the eccentric osteologist on the many different unsolved cases she comes across—usually in the form of decomposing bodies. But with so many incidents happening around them, could there be a larger mystery at work in their lives?

Sakurako-san no Ashimoto ni wa Shitai ga Umatteiru is a story of two unlikely partners, each showing in their own way that bones can tell how one died, but only people can tell how they lived.

Ruco plays Luk Kung Ji, he's a Malaysian tour guide, loves to play and sweet talks, but his real job is a Hong Kong music producer. He fled to Malaysia because he broke up with girlfriend Hong Yi Kiu (Elaine Yiu), then met Law Sik Sik (Aimee Chan), who also fled to Malaysia because she broke up with her fiance Ching Jin Pok (Matt Yeung). Aimee becomes the head of the travel agency after going to Malaysia and meets Ruco there. They became a bickering couple and developed feelings, but Ruco still had a knot in his heart and so they were unable to develop further; Ching Jin Chan (Lin Xiawei) is a silly girl who easily falls in love. Because Ruco showed some care for her, she fell in love with him and later falls for dessert chef Chin Chun (Tony Hung) too. Since she loves desserts, she asked Tony to be her cooking teacher and later finds out he has a crush on Aimee. She captured it on video and used it to threaten Tony to fulfill 3 wishes for her; Tony and Aimee are best friends, like sisters, but Tony secretly loves her. He's a strict person and is a hardcore instructor to Lin Xiawei; Elaine is a singer-songwriter, dated Ruco before; Matt and Lin Xiawei are siblings, and Aimee's ex-fiance. In front of Aimee, he acts very loving and caring, but in fact he's a player. He cheated on her with Wong Kei Ying (Samantha Ko); Samantha was Aimee's good friend, but the intimate clips of her affair with Matt were exposed at Aimee and Matt's engagement party, the couple broke up instantly.

Hong Sun Hee is a housewife who accidentally meets her first love, Jang Dong Chul, again. Now he is known as Song Jae Bin and is a famous movie star who didn't recognize her. Sun Hee's husband lands himself in jail for debts and Sun Hee applies to the wealthy Dong Chul for aid. He isn't inclined to help her bacuase she's no longer the beauty she once was but eventually she moves into his house as a housekeeper. The two bicker constantly but slowy they discover the feelings they had at 19 aren't completely gone.

Petch is a perfect, confident, and flirtatious rising businessman owner of Star Diamond the largest diamond Company. Mookda is an international policewoman with special training in Aikido who disguises herself as a nonsensical, troublemaker secretary to investigate the stolen diamond Adorella. As crazy as Mook is, Petch cannot help falling in love with her.

Inspector Chanathip has to go undercover to investigate a drug dealer gang disguised as the manager of superstar Nubdao, after she got shot by someone for being in possession of a memory card that has a client list of an International Drug Dealer Organization. Chanathip must pretend to be gay, and take care of Nubdao who is dirty and lazy. At first, they're always fighting because she dislikes him, but they eventually start falling for each other. That's just the beginning of their chaotic relationship...