Kurumi Nanba (Ai Hashimoto) is a student majoring in math at prestigious university. She's viewed as a weirdo due to her poor communication skills, but having a genius level intellect. Meanwhile, Tatsuhiko Handa (Kengo Kora) is a young detective. Kurumi Nanba and Tatsuhiko Handa work together to solve difficult cases including a series of bomb explosions, a locked-room murder and corporate blackmail.

Tendo Kaito is the son of the chairman of Tendo Memorial Hospital, one of the largest hospitals in the nation. Due to a bad relationship with his father, he did not become a doctor. Kaito now works as a magazine reporter. He is busy with his job and he also about to propose to his girlfriend. One day, he then learns that his father got involved in an incident. He goes to his estranged father's hospital. Due to the incident, Kaito becomes to know his father’s true intentions and he remembers the precious promise made with his father in the past. Kaito learns of the various problems hidden in the hospital left by his father and of the power struggle about to take place for the chairman position. Kaito decides to fight against the power struggle to take back the precious things his father built and to protect the ones who he loves.

Serizawa Yusuke works at a law office. He gets into a car accident. A woman helps him and she looks familiar to him, but he doesn't remember who she is. Yusuke Serizawa looks back at his past romances.

Wan Sheng Ren had accepted long ago the responsibilities and the parental interference that came along with his privileged life. Yet when it came to his marriage, he insisted on marrying the "little angel" girl from his childhood. His search for the girl led him to a family-operated inn, where he realized that recognizing his first love was more difficulty than he thought. Along with his personal assistant/bodyguard, Long Shi, they went undercover at the inn as their newest seasonal employees while they tried to figure out which of the women was his "little angel": A) Older sister Xu You Ai, tenacious slave master; B) Middle sister Xu You Qing, soft-spoken single mother; C) Little sister Xu You Meng, compulsive shopaholic; or D) Best friend Zhang Yin Yin, shameless man-eater.

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Jiang Yi Yi is a graduate student majoring in artificial intelligence. Ever since her twin sister passed away, she has been carrying a sense of guilt and has been determined to develop an AI that can "resurrect" her sister. This led her to be enter the world OG "Al Guru", Gu Yu.

Gu Yu, althouth hailed as a master in the field of AI, has a little-known mental illness. He has been searching for his childhood "Green Plum" to cure his illness, but by coincidence, he found Yi Yi, the older sister of his "Green Plum".

These tw "romantic fools" who should not haven fallen in love, gradually grew closer to each other during their joint research project, at their values aligned. As they helped each other solve problems, the seeds of love began to sprout.

The story focuses on the conflicts between the young teachers and the problems that high school students have. Jang Yi San is a timid and incompetent homeroom teacher who has to teach the only daughter of a highly dangerous mob leader, Eun Byul. Eun Byul is a new student at MyungMoon High with little drive to succeed.