The drama revolves around a mother who gets involved in her daughters' marriages which causes more harm than good. Deul Ja (Lee Mi Sook) is a strong, meddling mother with daughters to marry off. She owns a cosmetics store and raises her two daughters on her own. She considers money the most valuable thing in the world — which makes her single-minded in the pursuit of prospective son-in-laws. Her own marriage experience was unhappy, so she’s set on making sure it’s different for her children. She marries off the elder daughter to a doctor, then turns her attention to the younger daughter, Hye Yoon (Jung So Min) but only to have the daughter reveal that she wants marry to an ordinary salaryman, Jung Hoon (Sung Joon)

Tony, a playboy, just graduated overseas and is ordered by his father to work on a fried chicken shop of the family business. He has to improve the sales in 3 months, otherwise he will be forced to get married. It's not easy for him to work at the shop, especially since he has to hide his true identity.

Things get more complicated when he creates trouble and becomes enemies with the beloved daughter of a very strict military general. They bicker but eventually develop feelings for each other.

A girl accidentally arrives in a world inhabited only by men. Through her experiences, she finds love, friendship and learns the meaning of sacrifice. Wang You Ya is dealing with two big blows in her life. Not only is she distressed because of the boy that she likes but she also fights for her life because of a terminal illness. When she decides to participate in a hibernation experiment, she surprisingly awakes in a world full of men. Because of how rare she is, You Ya is hailed as a goddess.

Yook Dong Sik was running away from the scene of a murder and got into an accident. After waking up, he had no recollections of his memory and does not even know who he is. He only has with him a diary that recorded the process of murders and mistakes himself as a serial psychopath killer.

Yook Dong Sik, a 34-year-old employee. He thinks that he is a psychopath. He is so weak and timid that he can’t refuse anything at work and people at his office are using him. He became the scapegoat at his company. All his friends, colleagues and family are turning his back on him. He decided to leave this world and even wrote a suicide note. The place he decided to commit suicide is the murder scene. He got amnesia because of an accident at the scene and got the psychopath’s dairy in his hands. When he woke up, he thinks that he is the murderer.

Shim Bo Kyung, a 30-year-old, neighborhood police officer. She meets Dong Sik when he has amnesia. The more she knows about his story, the more she finds an unexpected look in him. She wants to catch the serial killer with Dong Sik as a partner of investigation.

Seo In Woo, 36-year-old, the director of the company Dong Sik works in. He is a cold and meticulous psychopath who lost his diary. On the day of his 7th crime, he met Dong Sik and things went wrong. He lost his diary where all his daily life and course of crime was written.

60 years after World War II, Keiko and her younger brother Kentaro begin a search on their grandfather's, Kyuzo Miyabe's (Osamu Mukai), life. Keiko is a freelancer journalist and Kentaro is soon to take his bar exam.

During their research, they learn that other people that knew their grandfather view him as a coward. Their grandfather believed life was the most important thing. He was also a talented pilot during the war.

Through their search, Keiko and Kentaro become confused on why their grandfather Kyuzo Miyabe boarded the Zero fighter plane and lost his life, even though he desperately wanted to come back home alive to see his daughter. Keiko and Kentaro begin to learn the truth.

A drama depicting a sweet twist in love between the parents and children of three families around the love of two main characters.

O-negative drama is remake for O-negative movie (1998). It's about the story of five friends who loved decorative arts.

They met randomly during the ceremony on the first day of class. One day, the freshmen were required to donate blood. They learned then that the 5 of them have the same blood type, O-negative.