High school student Watanuki Kimihiro has the ability to see spirits and monsters but is actually plagued with them. Coming home one day, he’s once again assailled by evil apparitions but his feet lead him to a strange shop. There he encounters Ichihara Yuko, the mysterious owner who offers to grant Watanuki’s wish to be rid of the spirits. But the price must be of equal value, so Watanuki has to temporarily work for her in her shop that grant wishes. Thus begins his adventures in an world full of supernatural experiences.

Adapted from the manga "xxxHOLiC" by Clamp.

Shinsei Hospital stands towering over its surroundings in the suburbs. At one time, this hospital which has been deeply entrenched in the local community, was one loved by the people. Everything seemed to be going well for it until a wrench was thrown one winter night in 2015. An unidentified woman with no personal belongings and in the final weeks of pregnancy was rushed to the hospital. Furthermore, there was evidence that she had attempted suicide. As a result, an indescribable mood of disquiet began to hang in the air at the hospital. One winter night some 20 years, a pregnant woman who tried to commit suicide was rushed to Shinsei Hospital in the same way. Although she did not survive, the foetus was saved through a C-section. However, the hospital forged the medical records to make it seem as if the foetus was stillborn, and the newborn baby was given the name Eiko. Were these two incidents a pure coincidence? Or intentional? The doctor Komoto Hideaki, who is the son-in-law of Shinsei Hospital director Komoto Junichiro, entered the emergency room. But the moment he saw the unidentified woman’s face, his expression hardened. Imaizumi Nao, a nurse at the hospital, took care of her. However, the woman never said a word. Junichiro’s only daughter Mie, who is also Hideaki’s wife and the hospital’s head nurse, reacted adversely to the woman’s occasionally sinister smiles and tried to get her out. As the dots between the two incidents connect, the dark side of Shinsei Hospital is gradually revealed. Status, prestige, desire, jealousy and vengeance. The complex web of human relationships around the hospital along with crime to cover up crime sets the hospital on course to collapse. Back in 2015, Nao was suffering from a curse because that unidentified woman entrusted her with something. What is Nao’s fate now?

The series follows a school bully who chance upon special powers, which can be strengthen by studying. Along the way, the bully made friends and found a new meaning in life as his strength grew.

Due to an incident, An Ding unleashes a miraculous ability to turn inanimate objects into people, but only for the duration of 24 hours. As the things in An Ding's house become human, it starts them on a bizarre yet dangerous adventure.