A manga artist, He Jie has entered into his own manga “Crystal Love” and he must complete the mission of saving the evil second female lead, turning her into a better person before he can return back to the real world. He ended up having to keep on filling up the loopholes of his own manga again and again, forming a funny lovestory.

In 1941, the mainland China was torn by war and Shanghai was fallen into enemy’s occupation. Xue’er and her family moved to a concession. The needy and difficult life there had eaten up the courage and conscience of Gui Ting, Xue’er’s husband, so he left his wife and child, and made up with his old girlfriend Liao Wanzhen who was born into a rich family. All hope was gone; Xue’er was about to commit suicide when Bai Lang saved her and introduced her to the entertainment world. Qiao Xiannong, a Shanghai magnate, was determined to win the heart of the beautiful and famous Xue’er; while Xue’er wanted to take back her son by taking advantage of Qiao’s power. Unexpectedly, her son fell down from the building and died, which is a grave blow for Xue’er. So she started a relationship with Qiao, aiming to retaliate against Gui by the aid of Qiao’s wealth and power. In order to win back Xue’er, Bai agreed to Wang Jianguo’s offer of assuming the chief of investigation bureau in the puppet government. After efforts and hardship, Bai finally won back Xue’er and married her. However, Qiao, who still desired Xue’er, instigated and assisted Xue’er to take revenge on Gui. After all, Xue’er was kind in essence. With Bai’s timely warning, she realized and corrected her errors. She gave up the notion of retaliation and wanted to lead a happy life with Bai. Seeing clear Wang’s intent, Bai was bitterly regretted. In order to save Bai, Xue’er sold her body and committed suicide by taking poisons.

Dr. Kaede Kojima (Matsushima Nanako) is now the staff leader at Minato University Hospital's Emergency and Critical Care Center. It's been a month since she took that position. She's calm and precise in her role as staff leader, but she doesn't let others get close to her. The relationship between staff members is awkward because of this. Others can't figure out why Hospital Director Tooru Mogami (Danta Yasunori) put Kaede Kojima in her position. One day, a patient's family asks the hospital to stop a donor transplant. Hospital Director Tooru Mogami calls Dr. Kaede Kojima in for a meeting. When Kaede Kojima gets there, Tooru Mogami and Yasuhiro Sugiyoshi (Tezuka Toru) wait for her. Yasuhiro Sugiyoshi complains about the cancellation of the donor transplant and blames staff members for not persuading the patients' family enough. Tooru Mogami then reveals that he invited donor transplant specialist Dr. Mamoru Natsume (Tokito Saburo). Around this time, tragedy strikes with multiple stabbings and an explosion. The Emergency and Criticial Care Center is inundated with injured victims. Chaos ensues as the staff fails to work together and the doctors do not cooperate or communicate with each other.

"Why do I need to choose and give up between work, love, and friend?" It is the office romance of the office couple Seol and JungWoo and Seol's childhood friend TaeHwan who enters the company KOGAS.

The chain of flowers between Rinka, Miyuki and Satsuki become connected as secrets become revealed.

Rinka (Nao Matsushita) lost her parents 13 years ago in an accident. Since then, she has lived with her grandmother. Her grandmother is then diagnosed with stomach cancer and becomes hospitalized. Making things worse for Rinka, the English institute where she works goes bankrupt. Paying for her grandmother's surgery seems nearly impossible.

Rinka then thinks of K. K sends a bouquet of flowers every year. Rinka thinks if she can find K, that person might help her. But who is K? Rinka asks her grandmother about K, but her grandmother doesn't say anything. Rinka then sends a letter to K and, later, a man who identifies himself as K's secretary appears in front of her. Rinka tries to find out K's identity and why he keeps sending flowers.

Miyuki (Miki Nakatani) married Kazuya 3 years ago. Kazuya worked for her uncle's company. The only thing Miyuki worries about is that they don't have children yet.

Kazuya's dream was to become an architect, but he now works in the sales department for an architect firm run by his wife's cousin Yosuke. Kazuya then participates in a competition to design an art gallery. Kazuya wins the competition, but Yosuke placed his name on Kazuya's design.

After Miyuki complains to Yosuke about his actions, Kazuya tells her something that has been on his mind. This causes tragedy.

University student Satsuki (Erika Toda) joins a climbing club with her friend Kimiko. Satsuki falls in love with Koichi who is in the same club. When Satsuki views Kocihi as part of her fate, Kurata, from the climbing club, collapses from leukemia.

Satsuki and Koichi take a test of their white blood cells. Satsuki finds out that she has the same white blood cell forms as Kocihi. A shocking hidden truth is reveled.