This is a story about an ordinary family struggling to become residents of Chungdam Dong, a rich neighborhood in Korea equivalent to Beverly Hills in LA. Kim Hye Ja is a housewife living in the countryside who has never lived in Seoul before. One day, she finds out that a friend from her hometown who owned a comic shop in Chungdam Dong died by accident. She decides to move into the deceased friend’s apartment on the store's second floor with her entire family, finally fulfilling her dream of becoming a coveted resident of Chungdam Dong. However, their new home is an old, broken down apartment which is nothing like the luxurious living place common in their former neighborhood. In fact, nothing has changed except for her address. Now, she has to live amongst the Chungdam Dong residents. The story depicts an interesting struggle between becoming rich and being genuine, among various people including Ji Eun, her daughter who dreams of living a luxurious life, Sang Yeop, a young man in the neighborhood, Gwan Woo, the boss of a defunct entertainment agency, Bo Hee, a famous actress from the past, and other various Korean Wave stars.

Goro Zaizen and Shuji Satomi are assistant professors at Naniwa University Hospital. Goro is a brilliant surgeon who will do anything to make his way up the corporate ladder. On the other hand, Shuji is a physician who earnestly devotes himself to medical research. Though the two doctors have contrasting personalities and are considered to be rivals, they highly recognize each other's skills. The entire medical department is restless while preparing for the election to choose a new Surgical Department Professor. All Goro has on his mind, is how to win the election. Meanwhile, Shuji is looking after a patient who apparently has pancreatic cancer. He carries out tests on the patient cautiously, and is very careful in telling the patient of the cancer. However, Goro barges in on their conversation, and out of the blue, tells the patient he has cancer, and that he needs an operation right away. Shuji is furious at Goro's rude attitude, and yells, "Doctors are not God!" Goro ignores this, and starts laying the groundwork for the operation. But when Goro finds out that the Director of the Medical Department has already given a diagnosis of stomach cancer, he cancels the operation. He feels that pointing out his boss's misdiagnosis will only hurt him in the upcoming election. Shuji however, is determined to save the patient's life and go on with the operation.

Spanning from 1925 to 1949, the series focuses on three children of a big family in Liling county, Hunan province and their search for a political path in the chaos of 20th century China. Their life is set against a number of significant historic events, such as First United Front, Second United Front, the Second Sino-Japanese War (1937–45), Chinese Civil War and the foundation of the People's Republic of China.

Koo Do Han, a former lawyer turned detective, is on a quest to uncover the truth behind an unsolved crime from the past. He investigates current cases to piece together clues to find the perpetrator. Along his journey, he encounters Cheon Na Yeon, an eager reporter, and No Sang Cheon, a con artist. Together, they work to unravel the truth and bring justice to the case.

The story centers around the employees of a legal document firm. Tamura Katsuhiro is a young man with a strong sense of justice. Although he believes that the law isn't always right, he becomes an administrative scrivener with the goal of manipulating the law in order to protect the weak. On the other hand, Sumiyoshi Misuzu, a former delinquent who hates to lose and who is now a capable scrivener. Katsuhiro and Misuzu are always at odds, but they gradually come to understand each other.

Himekawa Reiko became an assistant inspector with the Tenth Homicide Section at the young age of 27 even though she was not on the career track. As the only female section chief in the First Investigative Division, she leads Team Himekawa, armed with her intuition, dramatic ideas and energy, and has solved many challenging cases. Her older subordinate Kikuta Kazuo , a sergeant, is initially skeptical of her when he is transferred to the team. However, he gradually comes to realise her competence and charm, and special feelings begin to grow. Reiko’s nemesis is Katsumata Kensaku , an assistant inspector with the Fifth Homicide Section. Although he boasts an overwhelming lead in the number of arrests, his illegal investigation methods have also drawn suspicion.

Detective Investigation Files is a Hong Kong crime investigation drama series that features five different cases.