Yosuke Tomikawa (Tomokazu Miura) is married to Mizuki (Hitomi Kuroki). They have a daughter, Shiori (Atsuko Maeda), and son, Ko (Asuka Kudo). Yosuke works as the general manager in the personnel department at a large company. His wife works as a teacher at a private middle school. Their daughter works as a jewelry maker and their son is looking for a job. The family appears to look like a peaceful family, but, due to an accidental opportunity, the family begins to collapse.

Best Couple's background is set in modern day Korean entertainment industry. The story is about two top stars entering into a fake marriage with their own secret agendas, and through their efforts to defend their fake marriage in public, they learn about about each other's pains and weaknesses and eventually end up together. The male lead comes from a poor background and through hard work becomes a top star. He finds himself emotionally involved with his first love, fake wife and admirer. The female lead comes from a chaebol family and is an arrogant top star. She is neglected by her parents and due to a family feud/conspiracy, she must act strong in order to survive even though she is weak at times. Through a fake marriage, these two people find true love and their true selves.

Mal Ja, who is a part-time worker at a PR company, loves all living creatures but has experienced trauma with horses. Pebbles, her best friend, would like her to be something more and feels threatened by the arrival of a jockey who shows interest in Mal Ja.

Shakeela works as a maid in an upper-class family of Nadia. Nadia's daughter Hafsa's marriage decides to take place with Samad. In order to made arrangements of the marriage and to serve as helping hands Shakeela stays at Nadia's house along with her daughters; Zeba and younger Farah. Zeba, a college-going and educated girl comes across with there Sahil, Nadia's son suffering from [Down's syndrome]. At night, everyone is busy in the functions of marriage that Zeba receives call from Hashim who is Zeba's fiancé. He demands to see her and calls him in an under-constructed building. Zeba first denies but later agrees to meet him due to his insistence. Zeba goes there and someone rapes her. She comes back where everyone is already looking for him. She enters with Samad from the main gate and everyone there mistakes Samad as a culprit. Zeba is taken to hospital where doctor changes the reports as Siraj had already called him and ordered him to decalare her as a patient of Hysteria. Doctor does so and disappointed Zeba goes to her home with her mother.

A story of love, jealousy and selfishness from mother to son. Causing a young orphaned father like him to separate from his mother who suffered abuse and amnesia and disappeared. He set out to find his mother. With her, a sister from another lineage, to help until love grows The closer he gets to his mother, the more secrets are revealed. Both the true birth of the mother AND the murderer who killed his father and his benefactor.But that's not as bad as knowing that the culprit is his unexpected closure.

Ji Soon Young loses her husband, Wang Se Joon, in a tragic accident. She is left alone to take care of their adopted daughter. She meets and falls in love with Han Kyu Jin, who just happens to be the father-in-law to her former sister-in law, Wang Se Bin. Their lives changes when Soon Young marries Kyu Jin and becomes Se Bin's mother-in-law. They have to adjust to their new roles in their family and at the same time try to get along with each other.

The story is of how Lu Yi Ping tries to take revenge for her mother's sufferings and her, while torn between trying to find the meaning of love and forgiveness in her disfigured world. It is a story of how the love between her and He Shu Huan grew, under the most pressured and difficult circumstances. A story of Shu Huan's dedication to patiently teach love and forgiveness to Yi Ping. It is a story of a father's harsh relationship with his unwanted daughter and how it is rekindled. It is a story of an impossible crush, that somehow became reality. It is a story of a wife, forever faithful to her husband, and another's unfaithfulness. As a whole, it's a story of true love, compassion, revenge, lust, family, relationships, war, victory, friendship, respect, secrets, lies, deception, forgiveness, power, good, evil and much more.

The 65 episodes long series was divided into four parts: The Legend of Mo-fa (無花傳奇), The Great Desert (大沙漠), Legend of the Divine Palace (神宮傳奇) and The Final Battle (最後一戰).