Sui Tang Yanyi begins in the 580s with the conquest of the Chen dynasty (557-589) by the Sui dynasty under Emperor Wen, and concludes with the return of the Tang dynasty's Emperor Xuanzong to the capital Chang'an in 758 near the end of the An Lushan Rebellion (755-763).

The plot is made up of three main story lines.

The first, with Emperor Yang of Sui and his concubine Zhu Gui'er (朱貴兒) as the central characters, covers the events in the political arena and inner palace in the final years of the Sui dynasty.

The second story line narrates a turbulent period known as the transition from Sui to Tang, when heroes such as Qin Shubao,Shan Xiongxin (單雄信), Cheng Yaojin (程咬金) and Xu Maogong rise up to overthrow the Sui dynasty, followed by stories of how Li Shimin (the future Emperor Taizong of Tang) defeated his rivals and eventually solidified the Tang dynasty's sovereignty over China.

The last story line tells of the romance between Emperor Xuanzong of Tang and Consort Yang, and the events of the An Lushan Rebellion.

Here comes the story of a heart-warming and down-to-earth modern family! Duk Hwa, a former celebrity who married a hot wife who is 20 years younger than him. Keum Pyo, a first-born daughter in her second marriage after a failure of her first. Eun Pyo, a second daughter who's down-to-earth and born to love a man. Dong Pyo, a bigmouth phony-baloney living his restless youth. These outrageous members reveal their stories as their family feud unfolds.

No matter how hard he thinks about it, Todoin Seiya cannot figure out why he doesn’t have a girlfriend in his 16-year lifespan. Physically attractive, naturally smart, athletic and, on top of that, comes from a wealthy and politically significant family. And it’s not like he hasn’t tried either, but every girl he asks out flat out rejects him. Seiya sets a goal for himself to get a girlfriend by the time high school ends and rejection isn’t going to stop him from trying again. But it sure is heartbreaking when you get rejected this many times without knowing why.

We all experience birth, old age, sickness, and death. Yet have you ever wondered who determines the time of our death? Respected pharmaceutical doctor Kong Tung Kin starts up his own clinic after a drug trial incident. One day, he is approached by Toi Fung, who claims to be Satan, for a patient’s life. Refusing to do so, he suggests handing over his own. His reaction takes Fung by surprise. With a view to getting to know more about human beings, Fung interferes with Kin’s life, including his family and career. In addition, he runs after Fong Siu Fong, a nurse Kin has been secretly in love with. Later, Kin sells his soul to Fung for money and fame. As time goes by, he starts to become a totally different person, losing his kindness without himself knowing it.

Mal Ja, who is a part-time worker at a PR company, loves all living creatures but has experienced trauma with horses. Pebbles, her best friend, would like her to be something more and feels threatened by the arrival of a jockey who shows interest in Mal Ja.