This series is about four couples who live in the same house, With Love house.

Nathee is a country boy who passed the entrance examination to a university in Bangkok. Prin is from a wealthy family but he's not in friendly terms with his father, so he ditched the expensive condo and rents a cheap room instead. The landlord cheated these two and they had to stay in the same room.

Thunn has been living with his family in Korea for many years, but decided to attend a Thai university. He meets Kavin, who was his first love. Kavin wants to get back together with Thunn, although he already has a girlfriend, Irin. Kavin can't let them know about each other.

Kaowkla is a senior architecture student who teaches art in his free time. Plod, a high school kid came to visit Prin, who is his brother. Plod asks Kawokla to teach him as well and falls in love with Kaowkla, but Kaowkla only thinks of him as a younger brother. But Plod doesn't give up easily.

Burapa and Tawan are brothers and the sons of a well-known cop. They are very close as brothers. Burapa is into boxing, while Tawan wants to follow in their father’s footsteps to become a cop. One day, they hear a gun shot and go to see what is going on. This way, they witness a murder and when the time comes to point the finger at the killer, Tawan is not hesitant to do the right thing. Burapa knows that the bad guys will not leave their family alone and he begs Tawan not to be a witness. This is how the conflict begins.

Asagi Serina is a housewife who loves her husband, Takefumi, to the extent that she would not mind being his shadow. However, his response to her excessive devotion is to attempt to avoid her “burdensome”, “gross” expression of love. With a wife's naivety, she refuses to suspect her husband of infidelity, and initially gets frustrated. One day, with the help of her good friend, Motoko (Ashina Sei), Serina goes out for a meal with the men at the publishing company where Motoko works. The moment a man in the group makes a move on her, it is captured on film by the sleuth, Jinnai Haruki (Kiritani Kenta). Not wanting her husband to see the photograph, Serina starts working at Jinnai's detective agency as an assistant. This ordinary, bumbling housewife grows stronger and improves her self-confidence through the skills she hones. Serina wants to support and help her husband instead of flaunting her new self to him because he is having a hard time. Aware of the problem that happened to her husband because of her over positivity, she sets about trying to solve it. ~ Jdrama Weblog

Wai Yip-coeng (Chow Yun-fat) returned from the United Kingdom to Hong Kong as a lawyer. Instead of pursuing the law profession like his family wants, he got a job as a radio DJ at a local HK radio station. Lui Hei (Michael Miu), the young and inexperienced young friend of Wai tries to get a job at the station. He soon falls in love with Au Joek-zi (Angie Chiu) who seems to be only paying attention to Wai. He now wants a job more than ever at the station, but many guys were also interested in her. The story revolves around the rather gossipy late-1970s radio station life and work. The story also feature a few sub plots

Maneeyoung is a materialistic woman who plays many games with men. When she comes to realize her real love, it became a big disappointment as the younger man Ravee didn’t love her back and is in love with another woman at the same age.

Mayrisa's father comes from a rich family, but her mother was poor so she wasn't accepted by her father's family. They went to live on the countryside, where Mayrisa grew up with Aidin, her childhood best friend. One day, her grandmother takes her in and she goes overseas. 10 years later, Mayrisa and Aidin meet again as adults. She doesn't remember him anymore but he recognized her immediately. She was his first love and he's still in love with her, but because of their class differences he's trying to get over her and move on, but is always there when she needs help.

Shakeela works as a maid in an upper-class family of Nadia. Nadia's daughter Hafsa's marriage decides to take place with Samad. In order to made arrangements of the marriage and to serve as helping hands Shakeela stays at Nadia's house along with her daughters; Zeba and younger Farah. Zeba, a college-going and educated girl comes across with there Sahil, Nadia's son suffering from [Down's syndrome]. At night, everyone is busy in the functions of marriage that Zeba receives call from Hashim who is Zeba's fiancé. He demands to see her and calls him in an under-constructed building. Zeba first denies but later agrees to meet him due to his insistence. Zeba goes there and someone rapes her. She comes back where everyone is already looking for him. She enters with Samad from the main gate and everyone there mistakes Samad as a culprit. Zeba is taken to hospital where doctor changes the reports as Siraj had already called him and ordered him to decalare her as a patient of Hysteria. Doctor does so and disappointed Zeba goes to her home with her mother.