"22 Flower Road" is a webdrama about young people who share what they have and do not have with each other and become adults. It is expected to bring about realistic empathy with its highlights through the youthful lives of five young people.

Marvin's father is a very strict man and wants his son to follow in his foot-steps. Marvin on the other hand is really into the entertainment business, so he joins acting class. That's where he meets Torfun. She too is in the class. They meet each other a few times and they talk. Marvin even writes a song for her. There is a play coming up and they both audition and they both land the leading roles. He takes this opportunity to get closer to her.

Seua, the perfect guy in the eyes of many women, whom yearns for his father's love since he was a child, starts to feel sexually attracted to men and wants to stop it. Riawkhao, the girl he loves who also loves him, tries to turn the man back to straight. Moo on the other hand has a revenge in mind that involves Seua and Amber that started years ago. How will the family turn out?

Romania, 2005. One of the last vampire families on earth decides to disguise themselves and live among humans until "the glory of their empire" revives. They are sent to different places all over the world that are considered safe by their leader.

However, a group of vampires takes the wrong ship and happens to come to Korea. On board, they run into a timid and unlucky man Doo-il. One of the vampires bites him by mistake and he becomes one of them. They promise Doo-il that they will return him into a human on the day when their leader comes to find them. He doesn't have any other choice but to live with them. They are disguised as a family of five and start new lives in Seoul. Can they really go back to their country safely when their leader comes to find them?

While watching the vampires who disguise themselves as a human family, the viewers will witness both their human sides and the humans' inhuman sides. Can Seoul be a safe place for them?

Hyung Woo and So Young are a pair of orphaned siblings who live in Jae Goo's house. In this difficult family situation, Hyung Woo stopped studying properly and spent his time dreaming of a way to escape everyday life. Han Soo is his opposite; he works hard at school and is determined to live well in the future.

Naoko finds her life at cross-roads, as her career unravels after an unsuccessful project results in her demotion from marketing to data management, and her lover-cum-boss, Yanagiba Toshiro has left her to move to New York. When her life feels like it is at its lowest point, she meets Uchimura, a bus driver whose carefree yet caring approach makes her rethink her life's direction. When Toshiro unexpectedly returns to Tokyo, she finds herself caught between the two totally different men in her life.