Mari Sonoda heads to Keitaro's cleaning shop with his nephew Jotaro and meets Naoya and Masato, who has returned. Meanwhile, Smart Brain, which has become a governmental organization, has transformed into a company aiming to annihilate all Orphnoch life, and this operation is led by Kitazaki.
In order to protect the Orphnochs from extinction, Masato Kusaka fights against Smart Brain's enforcer, Reina Kurumi. Not only that, she is assisted by none other than Takumi Inui himself, who had disappeared years ago and returned as Kamen Rider NEXT Faiz to spearhead Smart Brain...!
Mari and the others are confused after being attacked by the new Faiz. Why is Takumi working with Smart Brain? What has he been up to since? Their turbulent reunion marked the beginning of a new story involving Orphnochs and humanity.