When Shoutarou Tatewaki first meets Sakurako Kujou, he knows his life will never be the same. Initially believing her to be responsible for a disappearance in the neighborhood, he later learns of her true talent: analyzing bone specimens. Sakurako has quite the collection of reconstructed animal bones, but she wishes she had more of the human variety, much to the chagrin of those around her. Soon, Shoutarou begins accompanying the eccentric osteologist on the many different unsolved cases she comes across—usually in the form of decomposing bodies. But with so many incidents happening around them, could there be a larger mystery at work in their lives?
Sakurako-san no Ashimoto ni wa Shitai ga Umatteiru is a story of two unlikely partners, each showing in their own way that bones can tell how one died, but only people can tell how they lived.
Michima Shin is a 30-years-old lonely and unpopular novelist who lives alone in a big house. Shin's father is a convicted murderer, awaiting capital punishment, who killed 3 people, including his wife, Shin's mother.
One day, five mysterious women showed up at Shin's house saying that they received an invitation to live with him in exchange of paying 1 million yen a month in rent. They set up rules for Shin such as no asking questions and no entering the women's rooms.
Six months later, Shin is used to the presence of those women, however, one day, an incident occurs that changed everything.