Lupin III (Shun Oguri), Daisuke Jigen (Tetsuji Tamayama), Ishikawa Goemon (Gou Ayano), Fujiko Mine (Meisa Kuroki) and Inspector Koichi Zenigata (Tadanobu Asano) meet. They face a powerful enemy and form the Lupin team in response. The Lupin team then faces the challenge of retrieving the "Crimson Heart of Cleopatra" locked away in a fort like safe. The treasure is thought to allow its owner to control the world.